Author + information
- Yaru Liang,
- Pinning Feng,
- Peisong Chen and
- Tang Jiang
Essential hypertension is the most common chronic disease which is related with an array of long-term target organ damage (TOD). Clinically, it would be helpful to detect high-risk patients early in development process of the disease, in order to avoid or delay the onset of TOD. The aim of our study was to evaluate the biomarkers which are possibly related to the development of TOD in essential hypertension, and identify the strongest predicting biomarkers.
Totally 377 consecutive patients who presented to the inpatient department of the First Affiliated Hospital of Sun Yat-sen University with a primary diagnosis of hypertension between January 2014 and February 2016 were recruited in our study. These patients were categorized according to the presence of TOD. Nineteen routine biomarkers, such as homocysteine, alkaline phosphatase, fibrinogen, uric acid, blood urea nitrogen, angiotensin converting enzyme and haptoglobin et al were evaluated in all subjects.
Hypertensive patients have higher serum Uric acid, angiotensin converting enzyme and haptoglobin levels than control patients. More importantly, blood urea nitrogen, homocysteine, alkaline phosphatase, white blood cell and fibrinogen levels were higher in the group with TOD compared with other groups. Three out of 19 biomarkers were significantly related with TOD in essential hypertension patients on backward elimination (multivariable-adjusted odds ratios, per SD increment in laboratory index) including: alkaline phosphatase (1.883; 95% CI: 1.375 to 2.614), homocysteine (1.620; 95% CI: 1.166 to 2.250), and fibrinogen (1.849; 95% CI: 1.354 to 2.524).
In conclusion, alkaline phosphatase, homocysteine, and fibrinogen levels were significantly higher in patients with TOD. According to our results, we suggest that the three biomarkers were the strongest predicting indexes to development of TOD in essential hypertension in our patient population.