Author + information
- Wang Huan and
- Chen Hui
CHINA STATUS (Survey of hyperTensive pAtienTs blood pressUre control rate in clinic Service) II is a prospective, multicentre, open-label, postmarketing, observational study including Chinese adults (aged ≥ 18 years) with essential hypertension who were prescribed once-daily valsartan/amlodipine (Val/Aml, 80/5 mg) single-pill combination. In order to observe lifestyle factors and antihypertensive response to Val/Aml, the data from the CHINA STATUS II study was further analysed.
A total of 11312 patients (6456men and 4856 women), received Val/Aml treatment for 8 weeks. After the treatment at 4 weeks and 8 weeks, we compared the proportion of patients not achieving the targetsystolic blood pressure (SBP; ≥140 mm Hg) or diastolic blood pressure (DBP; ≥ 90 mm Hg) in different lifestyle factors by T test or Chi-square test. There were hazard ratios (HRs) for not achieving the target BP by Mantel-Haenszel according to different lifestyle factors in men and women; the two-sided probability for the Fisher exact test was calculated.
Both women and men' appropriate physical activity can early achieved the target DBP (HR 0.92, 95% IC 0.88-0.97 in women and HR 0.91, 95% IC 0.88-0.94 in men at 4 weeks; HR 0.72, 95% IC 0.63-0.82 in women and HR 0.80, 95% IC 0.73-0.89 in men at 8weeks, respectively). There was the higher education, the more early achieving the target DBP in both women (HR 0.72, 95% IC 0.63-0.82) and men (HR 0.80, 95% IC 0.73-0.89) at 4week. Current smoke increased HR for not achieving the target DBP in women (HR 1.47, 95% IC 1.04-2.07) at 4 week, while BMI≥25 (HR 1.09, 95% IC 1.00-1.19 at 4 week and HR 1.32, 95%, IC 1.09-1.61at 8 week) and current alcohol drink (HR 1.31, 95% IC 1.05-1.63 at 8 week) increased HR for not achieving the target DBP in men.
Healthy lifestyle factors are important in control BP in patients with antihypertensive Val/Aml treatment.