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Primary aldosteronism (PA) is the most common form of secondary hypertension and associated with increased risk of developing relevant comorbidities. However, diagnosing Aldosterone-Producing Adenoma(APA), the major type of PA, is commonly uneasy in clinic. This study aimed to investigate the diagnostic value of aldosterone levels after the captopril and the saline infusion test for APA.
74 PA patients indentified by the confirmatory tests of captopril and saline infusion tests were enrolled into our study. After surgery, 40 patients was confirmed of APA (APA group) while the rests did not (NAPA group). The association between levelsof aldosterone after the captopril and the saline infusion test and APA was analyzed.
Thealdosterone before the captopril and saline infusion tests between the two groups were not significantly different. The aldosterone in the APA group after the two confirmatory tests was significantly higher than that in the NAPA group(220.7±19.4 pg/ml vs. 194.3±24.2 pg/ml, P=0.021 in captopril test, 200.5±16.2 pg/ml vs. 182.3±15.1 pg/ml, P=0.035 in saline infusion test). The area under the receiver-operating characteristic curve for detecting APA was 0.78, 95% CI: 0.64∼0.95, P=0.026 for captopril test and 0.85, 95% CI: 0.68∼0.97, P=0.002 for saline infusion test.
The levels of aldosterone after the captopril and the saline infusion tests could be the important diagnostic indexes for APA.