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To identify the and average number of antihypertensive agents (AHA) administered for hypertensive patients (pts) with concomitant diseases in Novosibirsk town cardiologists practice and to compare this data with European Guidelines 2013.
The study included analysis of prescribing in 320 Hypertension Grade 1-3 pts (143 men and 177 women 36-77 years old) with concomitant coronary artery disease (CAD) - 104 pts; atrium fibrillation (AF) - 82 pts; heart failure (HF) II-III NYHA -51 pts; diabetes mellitus (DM) - 50 pts, and chronic obstructive lung disease (COLD) - 33 pts. Hypertension anamnesis duration constituted 18, 2±1, 1 years, concomitant diseases anamnesis duration - 5, 7±0, 8 years.
More frequently administered AHA groups in CAD and AF pts were beta-blockers (BB) - 73, 1 and 68,2% and angiotensine-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) - 61,5 and 52,7%; in HF and COLD pts - diuretics (76,5 and 72,7%) and BB (72,6 и 54,6%); in DM pts - BB (74,0%) and diuretics (70,0%). Combined antihypertensive therapy was administered to 71-96% pts. In groups of pts with concomitant CAD, HF and DM more frequently administered combination of 4 numbers of AHA (31,7; 45, 1 and 26, 0% accordingly); in group of COLD pts - combination of 3 numbers of AHA (33, 3%), and in group of pts with concomitant AF more frequently administered combination of 2 numbers of AHA (29,0%). Coincidence of different groups AHA administration at real clinical practice with European Guidelines 2013 constituted 96, 0% in hypertension connected with HF and 91, 3% in hypertension connected with CAD and AF. On the background of 10-12th day of such therapy blood pressure control was achieved at 60, 6% CAD and COLD pts, at 62, 8% HF pts, at 64, 0% DM pts, and at 67, 9% AF pts. The most 6 month follow up compliance inherent to BB and ACEI/ARB. High compliance levels associated with marriage, education level, understanding of treatment benefice.
Cardiologists more frequently administered for hypertensive pts with concomitant diseases BB, diuretics (thiasides, indapamid, torasemid), ACEI. Administration 3-4 agents for one patient was prevailed. Coincidence of different groups AHA administration at real clinical practice with European Guidelines 2013 more frequently applied ACEI and BB at hypertensives connected with CAD, HF, DM and AF. Such therapy promoted blood pressure control from 10-12th treatment day at 60, 6-67, 9% pts.