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Metabolic syndrome(MS) was at risk factors of microvascular events and a higher prevalence of ischemic stroke. We evaluated the blood pressure(BP) and effects of arterial stiffness and pulse wave velocity, and wave reflections on central aortic pressure in patients with MS.
The study evaluated 325 patients with MS and evaluated by 24-h ABPM. Among the participants, classified as day high BP (awake BP >= 135/85mmHg and asleep ambulatory BP<=120/70 mmHg), Nocturnal high BP (awake BP <= 135/85 mmHg but asleep >=120/70 mmHg). And using radial artery application tonometry, aortic pulse analysis was performed.
112 Patients was observed nocturnal High BP. The estimated hazard ratio of silent ischemic stroke, using a fully adjusted model including the significant confounding variables of diabetes, augmentation index, asleep central aortic Systolic BP was significantly greater for patients with nocturnal High BP (2.04 [95% confidence interval: 1.95-2.32]; p<0.001).
Our results suggest that non-dipper, nocturnal BP is a significant increased ischemic stroke in MS. The highly significant predictive risk factor of silent ischemic stroke might be nighttime BP and central aortic systolic BP. Comparison of clinic BP with either daytime BP measurements or asleep BP measurements by AMPM might be particularly important in MS for the early detection of silent ischemic stroke event.