Author + information
- Cong Ma,
- Bingxiang Yu,
- Weihua Zhang and
- Qiang zeng
This study aims to comprehensively assess the influence of ALDH2 rs671 polymorphism on the hypertension risk in Chinese Han people. The effect of lifestyle on blood pressure in different genotype groups was investigated either.
The subjects were adult Chinese Han people who received heath examination in the period from January 2014 to December 2015. Detection of the ALDH2 r671 polymorphism was determined by polymerase chain reaction. Lifestyle data were collected using self-administered questionnaires which included 10 single food items with frequencies in 4 categories and exercise mode. Basic characteristics and fasting venous blood sample were collected at baseline.
4018 subjects were eligible for participation. The frequencies of the ALDH2 rs671 genotype were 68.67% (GG), 28.67%(GL), 2.66%(LL), respectively. ALDH2 rs671 polymorphism was significantly associated with hypertension risk (GG vs GL+LL: P=0.037, OR=1.285, 95%CI=1.016-1.625). No significant association was found between lifestyle and hypertension risk in GG genotype group. This relationship was independent of sex and alcohol consumption. On the contrary, there was a significant association between food frequency and hypertension in the GL and LL genotype group. The odds ratio (OR) for 1-2 times per week desserts intake with GL and LL genotypes was 0.581 [95% confidence interval (CI): 0.341-0.989 p=0.045], and 0.344(95% CI:0.148-0.799, P=0.013) for 5-7 times desserts per week intake. The odds ratio (OR) for 1-2 times per week fried food intake with GL and LL genotypes was 1.701 [95% confidence interval (CI): 1.028-2.815 P=0.039], 2.091(95% CI:1.035-4.224, P=0.040) for 3-4 times fried food intake and 3.532 (95% CI:1.289-9.674, P=0.014) for5-7 times fried food intake. In addition, there was significant difference in liver enzyme, blood glucose and lipids between the two groups. AST, ALT, γ-GT, TB, DB, TC, TG, HDL, FBG, PBG, UA were significantly higher (P<0.05) in the GG genotype group than in the GL and LL genotype group. Meanwhile, Cr, BUN were significantly lower (P<0.05) in the GG genotype group than in the GL and LL genotype group.
Our study suggested that the rs671 GG geno-type was a risk factor of hypertension in Chinese Han people. Lifestyle affects each genetype differently on the development of hypertension. Dessert intake is a protective factor for hypertension, while fried food is a risk factor of hypertension in the L genotype group. Differences in the metabolic parameters and liver enzyme of two groups may relate to alcohol consumption.