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To explore the associations between the metabolic syndrome (MS) and early renal damage in hypertension.
A total of 399consecutive patients were included in the cross-sectional study. Body height, weight, waist circumference, biochemical and serum lipid profile were measured. CKD was determined by GC formula estimated glomerular filtration rate (eGFR). Early renal damage was estimated by Albumin creatinine ratio (ACR). The MS was defined according to IDF (Intemational Diabetes Federation) definition.
(1) Compared to those without MS, BMI, 2h-BS, TG, HDL,DBP,UA and serum creatine were significantly increased, and eGFR was significantly reduced in patients with MS (P<0.05). (2) ACR increased in proportion to increasing number of the MS components and was the highest when patients had 5 components of the MS (P<0.05). While the association between eGFR and components of MS shows to be “parabola”, and the highest level appears when patients with 2 components of the MS (P<0.05). (3) In the Logistic analysis, IGF, elevated TG and blood pressure level were risk factor of early renal damage in hypertension (all P<0.05). After adjusted multivariate (adjustment for age, sex), IGF, elevated TG and blood pressure level were significantly associated with an increased odds ratio of early renal damage, 1.852, 3.622 and 1.6, respectively.
MS and MS components are obviously associated with early renal damage in hypertension, the risk of renal damage increased in proportion to increased number of MS components. IGF, increased HDL level and blood pressure level are independent risk factor to indirect early renal damage in hypertension.