Author + information
- Umida Kabirovna Kamilova,
- Tohirahon Alieva and
- Kodir Boboev
To evaluate efficacy of beta blockers - carvedilol and bisoprolol in the patients with chronic heart failure (CHF) in relation to the state of β1 - adrenoreceptors.
There were studied 72 males at the age from 40 to 55 years with postinfarction cardiosclerosis (PICS). All the patients were divided into two groups: group I included 55 patients with FC II CHF and group 2 was comprised of 37 patients with CHF FC III. In group I 17 patients and from group II 19 patients received bisoprolol and 18 patients in group I and II received carvedilolol. Genotyping was performed with PCR method.
There was noted initial increase in density of β2 - adrenoreceptors in the patients with CHF FC II and III y 176,2 and 204,9% (P<0,001), that was accompanied by desensitization of adenylate cyclase system: in the patients with FC II XHF the basal activity of edenylate cyclase was 4,15±0,14 pmol/mg/min, with FC III CHF 3,56±0,13 pmol/mg/min against 6,1±0,19 pmol/mg/min in control group. In genotyping there was noted that more marked reduction of basal activity was revealed in group Gly389 homozygote in comparison with group Arg389. During genotyping Arg389 homozygote carvedilol showed more strong effect. There was noted reduction of density of β2-AP in group Arg389 by 32,7%.
Treatment with carvedilol provided normalization of the correlation of beta-receptors in group of patients with genotyping Arg389.