Author + information
- Fan Fenling,
- Yushun Zhang and
- Anthony Dart
Whilst a patent foramen ovale (PFO) is commonly found in patients with crytogenic stroke (CS) causative mechanisms remain speculative and deep venous thrombosis is rarely found.
So the purpose to compare demographic, haemodynamic and haematological indices between patients of ischaemic stroke (IS) without PFO and those of CS with a high risk PFO.
All patients were less than 60 years. The study group was CS patients with a high risk PFO [PFO≥4 mm with big amount right to left shunt (RLS)], combined ≥1 high risk factors]had a high risk PFO], whilst the control group was IS patients without PFO. Venous blood samples were obtained before administration of any anticoagulation (3 subjects on aspirin). All patients underwent brain CT and 2D echocardiography. Measurements of full blood count, inflammatory markers, clotting parameters were made.
Patients without PFO were older (50±1 vs 44±2 years) and had higher systolic (138±4 vs 119±2) and diastolic blood pressure (87±2 vs 76±1 mmHg). Gender distribution was similar. Haematological parameters differed between the groups. In multiple regression analyses including age, significant differences were found for WBC, %monocytes, %lymphocytes, aPPT, PT, INR and fibrinogen. For patients aged 50 to 60 years significant differences in SBP, DBP, WBC, PT, TT, and fibrinogen were found between those with (n=29) and without (n=28) PFO.
Patients presenting with CS and high risk PFO are younger, have lower blood pressure and differ in a number of haematological variables. Differences are not accounted for by age and may indicate differences in stroke aetiology.