Author + information
- Zhang Li,
- Chuan Qin and
- Mingxing Xie
To investigate the value of applying echocardiography to evaluate cardiac dyssynchrony in patients with congestive heart failure (CHF).
A total of 348 consecutive CHF patients who were referred for cardiac resynchronization (CRT) and presented with low ejection fraction (EF) and wide QRS duration were enrolled in this study, along with 388 healthy individuals.
(1) Compared with the control group, FT/RR was decreased while PED, IVMD, LOWD and RSPWD were increased in the CHF group (P<0.01). (2) In the CHF group, FT/RR was negatively correlated with the QRS duration, LV end-diastolic diameter (LVESd), LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) (P<0.01) and positively correlated with the LVEF (P<0.01). Additionally, PED, IVMD, LOWD and RSPWD were positively correlated with the QRS duration, LVESd, LVEDV and LVESV (P<0.01) and were negatively correlated with the LVEF (P<0.01). (3) The CHF group was divided into three subgroups according to the varying degrees of LVEF. FT/RR decreased successively from the LVEF-1 group to the LVEF-2 group to the LVEF-3 group, while the PED, IVMD, LOWD and RSPWD successively increased in the same order (P<0.01). (4) The CHF group was divided into three subgroups according to the varying degrees of QRS duration, and FT/RR decreased successively in a sequence from the QRS-1 group to the QRS-2 group to the QRS-3 group, while the PED, IVMD, LOWD and RSPWD successively increased in the same order (P<0.01). (5) Speckle tracking radial dyssynchrony ≥130 ms was predictive of an EF response in QRS-1 interval patients (78% sensitivity, 83% specificity), QRS-2 interval patients (83% sensitivity, 77% specificity) and QRS-3 interval patients (89% sensitivity, 79% specificity).
Echocardiography is a convenient and sensitive method for evaluating cardiac dyssynchrony in patients with CHF.