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To study the clinical significance of Rheumatic Heart Disease (RHD) in patients with Ankylosing spondylitis (AS).
40 healthy controls and 60 patients with AS who visited the Third Affiliated Hospital of Sun Yet-sen University between 2012 to 2016 were included. According to history of RHD, patients were divided into AS group (group 1, n=42) and AS with RHD group (group 2, n=28). Anti-streptolysin O (ASO) and anti-DNA enzyme B in serum were examined by latex agglutination and enzyme-linked immunosorbent assay (ELISA), C-reaction protein (CRP) and erythrocyte sedimentation rate (ESR) were examined by means of standard clinical chemistry methods. Clinical symptoms and physical signs were observed. Radiographic grade were analysed.
Positive rates of ASO (40.48%) and anti-DNA enzyme B (52.38%) in group 1 were significantly higher than those in the control group (5%;10%;P<0.05), meanwhile they were observably lower than those in the group 2 (82.14%;89.28%;P<0.05). Compared with group 1, patients in group 2 experienced higher incidences of swelling and pain over knee and ankle, positive sign Schober Test, increased level of CRP and ESR, and cacroiliac joint X ray above phase II (P<0.05).
Streptococcal infection may contribute to the pathogenesis and the progression of AS. A history of RHD in AS patients might be a potential predictor of the severity and activity of AS.