Author + information
- Cao Haiyan,
- Yu Wang,
- Wei Han,
- Liu Hong,
- Yuan Peng,
- Yunfei Hu and
- Mingxing Xie
To investigate the application of fetal cardiovascular cast in the demonstration of aorta and/or aortic branching anomalies.
From January to June 2015, 18 cases with aorta and/or aortic branching anomalies diagnosed by fetal echocardiography were terminated upon parental requests. Fetal cardiovascular cast models were made by the method of corrosion casting technique. The casting material was injected into the specimen via umbilical vein. Then the adhesion tissue was dissolved by strong acid after the casting fluid was solidified, in order to demonstrate the real geometries. The origin, course, diameter, branching of aorta and aortic valve anomalies were carefully observed and analyzed.
A total of 18 fetuses prenatally diagnosed with aorta and/or aortic branching anomalies were enrolled in this study (18.2 to 34.7 gestational weeks), and all specimens were successfully made into cast models. Twenty-nine abnormalities in aorta and/or aortic branching were demonstrated by these casts, including: aortic origin anomalies in 9 cases (double outlet right ventricle 8/9, transposition of great arteries 1/9), aortic valve anomalies in 2 cases (aortic valve atresia 1/2, aortic valve stenosis 1/2), aortic diameter anomalies in 5 cases (dilation of aorta 2/5, coarctation of aorta 3/5), aortic course anomalies in 4 cases (right aortic arch 2/4, interrupted aortic arch 2/4) and aortic branching anomalies in 9 cases (aortic mirror image branching 2/9, aberrant right subclavian artery 1/9, common trunk of right brachiocephalic artery and left common carotid artery 4/9, left vertebral artery anomalously originated from aortic arch 2/9).
The fetal cardiovascular cast is capable of demonstrating aorta and aortic branching anomalies clearly and objectively. It will help us to understand the spatial relationship of aorta and its major branches, and to provide valuable information for prenatal diagnosis.