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Dobutamine as a traditional cardiac tonic used in post－cardiac surgery patients are commonly. Levosimendan is a new cardiac tonic, which in many studies had showed that it has a good efficacy on improving cardiac function, but less used in post-cardiac surgery patients. This study will compare the efficacy of levosimendan and dobutamine on post-cardiac surgery patients.
We include 45 post-cardiac surgery patients, which were randomly divided into dobutamine injection group and levosimendan injection group. Each group test cardiac output and echocardiography at baseline and 1 week.
The cardiac output (CO) increased overtime in the levosimendan group compared with the dobutamine group (P = 0.012). In levosimendan group, the improvement in the ejection fraction from 34.6 to 43.2% (P = 0.014) compared with the dobutamine group.
The study determines that levosimendan treatment on post-cardiac surgery patient provides a better clinical outcome compared with dobutamine treatment.