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To study the association between neutrophilic granulocyte percentage and depression in patients with chronic heart failure.
183 cases of chronic heart failure patients with cardiac function of New York Heart Association (NYHA) class II, III, IV and history of above 3 months were enrolled. The enrolled patients received Hamilton Depression Scale (HAMD) for depression evaluation. The red blood cell count, white blood cell count, neutrophils granulocyte percentage and serum total cholesterol, triglyceride, high density protein cholesterol, low density protein cholesterol, total bilirubin, creatinine, urea nitrogen, triiodothyronine, tetraiodothyronine, thyrotropin, thyroid stimulating hormone were documented. The Pearson simple linear correlation was performed to evaluated the confounding factors correlated with HAMD depression index. The significantly correlated factors were enrolled in Logistic regression for adjustment.
105 cases of chronic heart failure patients had depression while 78 cases of chronic heart failure patients didn't have depression. Pearson simple linear correlation revealed that in patients with chronic heart failure, the neutrophils granulocyte percentage was positively correlated with the HAMD depression index (r=0.435, P < 0.001). Logistic regression analysis showed that after adjustment of serum total bilirubin, creatinine, urea nitrogen, total cholesterol, low density lipoprotein cholesterol, triiodothyronine and NYHA classification, neutrophils granulocyte percentage was still a significant risk factor of depression in patients with chronic heart failure (OR=1.167, P=0.031).
The neutrophils granulocyte percentage was significantly associated with depression in patients with chronic heart failure.