Author + information
- Yao Fengjuan,
- Ye Min,
- Liu Yan Qiu,
- Fan Rui,
- Li Wei and
- Li Cuiling
we initiated this study to explore the relationships of serum phosphorus level with left ventricular ultrasound features and function in PD patients.
174 patients with ESRD receiving PD were enrolled. Conventional echocardiography examination and TDI were performed in each patient. Clinical information and laboratory parameters were also collected. Analyses of echocardiographic features were performed according to phosphorus quartiles groups. And multivariate regression models were used to determine the association between serum phosphorus and LVDD.
With the increase of serum phosphorus levels, patients on PD showed an increased E/A ratio (P = 0.018) and a higher tissue Doppler-derived E/e' ratio of lateral wall (P < 0.001), indicating a deterioration of LV diastolic function. Steady growths of left atrium (LA) and left ventricular (LV) diameters as well as increase of left ventricular muscle mass (LVM) were also observed along with the increase of phosphorus, while LV ejection fraction (LVEF) remained normal. In a multivariate analysis, serum phosphorus level was independently associated with E/e' ratio of lateral wall (β: 2.84, P < 0.001).
Our study showed an early impairment of LV diastolic function in peritoneal dialysis patients. High serum phosphorus level was independently associated with greater risk of LVDD in these patients. Whether serum phosphorus will be a useful target for prevention or reduction of LVDD remains to be proved by more studies.