Author + information
- Xiujuan Hou,
- Xiaoping Liu,
- Wei Zheng and
- Yuelan Zhu
Cardiovascular (CV) morbidity and mortality are increased in rheumatoid arthritis (RA). Chronic systemic inflammation is believed to be an independent risk factor for atherosclerosis. RA and OA for rheumatology outpatients in one of the most common joint disease, We compared carotid intima-media thickness (IMT) of both the common carotid (CCA) and proximal internal carotid (ICA) arteries, and plaque prevalence, between RA and OA participants.
The information of RA and OA patients hospitalized in Department of rheumatism, East Hospital, Beijing University of Chinese Medicine in 2015 were collected, including blood pressure, levels of ESR, CRP, and RA disease activity score (DAS28), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and blood uric acid (BUA); Color Doppler ultrasonography of carotid artery used to observe intima-media thickness (IMT), and plaque formation (bilateral common carotid artery-CCA, internal carotid artery-ICA) and the number of plaques, plaque score -Crouse score).
We compared 95 rheumatoid arthritis patients to 89 osteroarthritis patients. (1) there was a higher prevalence of hypertension in the RA group; (2)Blood TC, LDL-C and BUA were higher in RA groups than those in OA groups (P < 0.05,;P < 0.01), HDL lever in RA group was lower than that in OA group, (P > 0.05); (3)levels of ESR, CRP and platelet count in RA group were higher than those in OA group (P < 0.01);(4)ICA-IMT was higher in RA patients than controls (1.23 vs 1.06 mm, respectively; p < 0.01), while CCA-IMT did not differ significantly. the odds of plaque were significantly increased in RA participants compared to OA (OR 2.51, 95% CI 1.22-3.92).RA TC, LDL-C and OA groups (P < 0.05, P < 0.01), HDL than in OA group decreased (P > 0.05); (4) in patients with RA than in OA increased (respectively, 1.06 mm, P < 0.01); but CCA-IMT had no significant difference; carotid artery plaque incidence in RA was significantly higher in OA (or 2.51, 95% CI 1.22-3.92; LDL-C BUA crouse integral level showed significant positive correlation (P < 0.05). There was significant positive correlation between levels of LDL-C,BUA and Crouse point (P < 0.05).
Compared to OA, RA was associated with a higher prevalence and higher severity of atherosclerosis in the ICA. Our data suggest that carotid artery ultrasound measurement could provide evidence for the discovery of atherosclerosis in RA.