Author + information
- Ahmad Zare Javid1,
- Razie Hormoznejad2,
- Hojat allah Yousefimanes3,
- Mehrnoosh Zakerkish4,
- Mohammad Hosein Haghighi5 and
- Maryam Ravanbakhsh6
- 1Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- 2Student Research Committee, School of Paramedicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
- 3Dept.of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- 4Health research institute, Diabetes research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- 5School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- 6Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Diabetes mellitus and periodontal disease with a two-way relationship can affect public health and impact the quality of life. The aim of this study was to investigate the impact of resveratrol supplementation along with non-surgical periodontal treatment (NST) on blood glucose, insulin, insulin resistance, triglyceride and periodontal markers in type 2 diabetic patients with periodontal disease.
In this double-blind clinical trial study 43 diabetic patients with chronic periodontitis referred to the Endocrinology clinic at Golestan hospital in Ahvaz, Iran were participated. Subjects were randomly allocated to intervention and control groups. The intervention and control groups received either 480 mg/d resveratrol or placebo capsules (2 PCs) for four weeks. Non-surgical periodontal therapy was provided for all subjects in the intervention and control groups during the study. Anthropometric parameters, 24 hour dietary recall, fasting blood glucose, insulin, insulin resistance (HOMA-IR), triglycerides and pocket depth (PD) were measured in all subjects pre and post intervention.
The mean serum levels of fasting insulin and insulin resistance (HOMA-IR) was significantly lower in the intervention group compared with control group (10.42 ± 0.28 and 10.92 ± 0.9; 3.66 ± 0.97 and 4.49 ± 1.56 respectively). There was a significant difference in the mean pocket depth (PD) between two intervention and control groups (2.35 ± 0.6 and 3.38 ± 0.5 respectively) post intervention. No significant differences were observed in the mean levels of fasting blood glucose and triglycerides between two groups post intervention.
It is recommended that resveratrol supplementation may be beneficial as adjuvant therapy along with non-surgical periodontal treatment in controlling blood glucose and improving periodontal status among diabetic patients with periodontal disease.