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To evaluate the frequency of ED and androgen deficiency in men with high cardiovascular risk and metabolic dicorders.
The study included 300 men aged 30-59 with high cardiovascular risk on SCORE (>5%) and metabolic disorders, such as abdominal obesity (waist circumference>94 cm), dyslipidemia (triglycerides>1,7 mmol/l and/or HDL cholesterol <1mmol/l), prediabetes (IDF criteria, 2005). All participants were measured HDL cholesterol, LDL cholesterol, and fasting glucose as well as waist circumference and blood pressure. ED was evaluated by IIEF (<21 points). Androgen deficiency was diagnosed if level of total testosterone was decreased (<12 nmol/l) and/or level of free testosterone was decreased (<0,255 nmol/l) and if clinical symptoms of hypogonadism were present.
ED was diagnosed in 60,7% (n=182) of men with high cardiovascular risk and metabolic disorders. Mild ED was diagnosed in 18%, moderate ED in 33,7% and heavy ED in 9% patients. The frequency of ED noticeably increases with age. Androgen deficiency or hypogonadism was defined in 17% (n=52) men with high cardiovascular risk. In all cases androgen deficiency was combined with ED of different degrees. Hypogonadism was diagnosed in 28,6% of patients with ED and high cardiovascular risk. The patients with ED in 22,6% had 3 risk factors, 29,4% - 4 risk factors and 8,7% of men had 5 risk factors, included metabolic disorders.
Every second man with high cardiovascular risk and metabolic disorders has ED, one fifth - hypogonadism. For most men with ED revealed a moderate ED, which requires the simultaneous correction of risk factors and sexual dysfunction, including the use of inhibitors of phosphodiesterase type 5.