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To investigate the correlation between brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT) in the middle-aged and elderly participant subjects, and to analyze the main factors which affect baPWV and IMT.
We enrolled 505 participant subjects during their routine health screening. Clinical data collected by physical examination included age, sex, height, weight, blood pressure (BP). Fasting blood glucose (FBG), Total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total triglyceride (TG) were determined by standard procedures. baPWV was obtained using an automated device while IMT was measured by carotid ultrasonography. The correlation between baPWV and IMT and the contributing factors were analyzed. Then participant subjects were divided into three groups according to IMT, baPWV was compared in each group. The classification standard is IMT<1mm, IMT=1mm-1.5mm and IMT>1.5mm.
There is positively correlation between baPWV and IMT (P <0.0001, r = 0.3037). Moreover, baPWV elevates significantly associates with the increase of IMT (P <0.0001, F = 43.65). Age, blood pressure, TG, FBG are contributing factors of baPWV (P <0.005). On the other hand, LDL, TC, TG, FBG, age, BP, body weight affects carotid IMT (P <0.05).
Bapwv can objectively reflect the degree of arteriosclerosis and indicates the early changes in stiffness of blood vessels.