Author + information
- Zhao Miaomiao and
- Jue Li
To compare the incidence of adverse pregnancy outcomes at two time points (2001 and 2010) in Shanghai, and to evaluate the effect of pregnancy management and hypertensive disorders of pregnancy (HDP) intervention over the last decade.
We performed a retrospective double cohort study among women who underwent routine prenatal examination and subsequently delivered in Shanghai First Maternity and Infant Hospital and Shanghai Tenth People's Hospital between January 1th and December 31th in 2001 and 2010. The maternal and perinatal adverse outcomes were recorded for both time points for both non-HDP and HDP women. Chi-square test was used to compare the difference of adverse pregnancy outcomes during this period.
A total of 11130 women were analyzed after excluding pregnancy termination before 28 weeks of gestation, those having no information of maternal age at delivery and medical records with abnormal values. For non-HDP pregnancies, preterm, low birth weight (LBW), neonatal asphyxia, intrauterine growth retardation (IUGR), fetal respiratory distress syndrome (FRDS), perinatal death as well as umbilical cord abnormalities occurred more frequently in 2001 compared with those in 2010 (all P < 0.01). However, for HDP pregnancies, the maternal and perinatal adverse outcomes did not improve over time.
The incidence of adverse outcomes decreased in 2010 compared with 2001 among non-HDP pregnancies, while not in HDP. More standardized management and intervention during pregnancy are required, especially in HDP.