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Rhabdomyolysis rhabdomyolysis syndrome is a medical emergency, with a complex etiology, sudden onset, complex diagnostic procedures that can lead to clinical features of multiple complications. In recent years, its presence is gradually coming into view, appeared in a variety of medical events in the news. Corresponding rock climbing, mountaineering, skiing, surfing and extreme sports related to the outside temperature, leading to rhabdomyolysis cases is also increasing. This experiment analyzed various index of swimming rats under different temperature, aims to further explore the mechanism of temperature exercise-induced rhabdomyolysis syndrome, we can provide reference for rhabdomyolysis events which leaded by different environmental.
This study selected 40 SD rats after feeding in their natural environment adaptability week, the rats were randomly divided into four groups: normal control group, the low exercise group swimming, swimming group at room temperature, heat swimming group. In addition to the experimental group started the other three groups adaptive swimming training once a day, the time increments from 5 minutes to 30 minutes, then began a formal swimming. 50cm x 50cm x50cm training conducted sink, static depth 40cm, once started swimming every morning. The experiment was conducted 12 weeks, during which rats were measured immediately after every experiment rectal temperature, body weight was measured once every 3 days, after 12 weeks for the three groups of rats sacrificed immediately after exhaustive exercise, peritoneal venous blood of kidney and indicators gastrocnemius organizations rat blood creatine kinase (CK) levels, serum creatinine (SCR) level and myoglobin (MB) levels.
1. When the core temperature of hot and cold environment movement in rats with changes in the external environment changes, the ambient temperature affect the body's core temperature by increasing the degree of rhabdomyolysis syndrome. 2. Hot and cold environment than the normal temperature environment, the more impact CK and MB level, large temperature environments intensity exercise the same muscle tissue damage. 3. Serum creatinine level indicates the degree of kidney damage, extreme environments significantly elevated serum creatinine movement, the environmental movement, said the cold damage the kidneys, may cause acute renal failure. All test indicators, data were processed by statistical methods.
The movement of the body temperature environment in muscle tissue damage and renal function. The thermal environment in the body from exercise-induced rhabdomyolysis syndrome highest probability. At room temperature, high-intensity exercise will also cause damage, but a lesser degree of injury. Induced rhabdomyolysis syndrome produce large intensity exercise dominant, but in extreme environments Exacerbate rhabdomyolysis syndrome generation.