Author + information
- Gu Wei and
- Shaojun Wen
Background: Single nucleotide polymorphisms (SNPs) within β-adrenergic receptor (ADRB2) were shown to be related to lipid traits or hyperlipidemia in different ethnicities but not in the Chinese. We performed the present paper to investigate the possible relationship between them in a Chinese hypertensive population.
Seven hundred and eighty-three hypertensive subjects were enrolled in the hospital-based retrospective research. Using TaqMan PCR method, three polymorphisms (A46G, C79G and C-47T) of ADRB2 were detected.
For the whole population, no significant statistically difference was found for all serum lipids. Similar findings were seen in men and women subgroups. Subsequently in the case-control study, we observed that the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia in dominant model (OR: 1.47, 95%CI: 1.05-2.06, P=0.025). There were some marginally apparently differences in allelic model (OR: 1.24, 95%CI: 0.995-1.54, P=0.056) and additive model (OR: 1.23, 95%CI: 0.99-1.52, P=0.06). With regard to C79G and C-47T, no significant association was seen in this population. In addition, haplotype analysis showed that the TAC haplotype carrying frequent alleles of the three SNPs played a reduced role in hypertriglyceridemia risk and the TGC haplotype carrying rare allele of A46G expressed a significant risk effect.
These findings indicated that the ADRB2 SNPs might be a genetic risk factor for dyslipidemia in the Chinese hypertensive patients.