Author + information
- Yousef Rasmi2,1,
- Elmira Roshani-Asl1,
- MohamadHasan KhademAnsari1,
- MirHosein SeyedMohammadza3 and
- Alireza Rostamzadeh3
Alternation in the levels of angiogenic factors were reported in some cardiovascular diseases, which may affect vascular endothelial integrity. Endothelial dysfunction is the main pathological mechanism in cardiac syndrome X (CSX). Therefore, we aimed to investigate the levels of angiogenic factors in CSX patients.
The study included 30 CSX patients (17 female/13 male; age: 55.53±9.18 years) and 20 healthy age and sex matched controls (14 female/6 male; mean age: 51.40±9.169 years). Enzyme linked immunosorbent assay was used for the estimation of Ang-2.
There was a significant increase in the angiopoietin-2 levels in patients with CSX (277.02±186.08 ng/l,) than those without (164.46±49.83 ng/l) (P=0.011). The BMI, systolic and diastolic blood pressure were not significantly changed in patients with CSX in comparison with controls (P>0.05).
Results showed abnormal levels for Ang-2 in CSX patients. Ang-2 can be used as a biomarker of CSX. Ang-2 abnormalities may consider a possible role for these angiogenic factors in the pathophysiology of CSX, at risk of developing CVDs.