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Myocardial infarction is one of the most serious cardiovascular diseases and is associated with considerable morbidity, mortality and disability rate. Myocardial fibrosis (MF) is an important pathophysiological change after myocardial infarction, which can lead to ventricular dysfunction, irreversible arrhythmia, heart failure, even cardiogenic sudden death. MF after myocardial infarction is tightly associated with the development and prognosis of the disease. However, currently available drugs against MF after myocardial infarction are still very limited. Ginkgo biloba extract is a well-known drug showing high physiological activity in therapies for diseases and is widely used more than 130 countries as a drug or food additive. Ginkgo biloba extract 761 (EGb 761) is a well-defined extract obtained from Ginkgo biloba leaves according to a standardized method. Consequently, a potential use of EGb 761 in lung fibrosis has been proposed. Therefore, this study was performed to investigate the role of EGb 761 in the MF after myocardial infarction.
Adult SD rats were randomly divided into: sham group, model group, and model + EGb 761 group (25 mg/kg, 50 mg/kg, and 100 mg/kg subgroups). The left anterior descending coronary artery was permanently ligated in the model and model + EGb 761 groups. The sham group was subjected to all procedures excluding permanent coronary artery ligation. The effects of EGb 761 on the MF after myocardial infarction were observed by hyaluronic acid (HA) concentration and Masson staining.
Compared with the sham group, HA content was significantly increased in the model group. HA content was significantly decreased in the model + EGb 761 group compared with model group. Masson staining revealed that no blue area and inflammatory cell infiltrate was detected in the sham group. However, normal cardiomyocytes were replaced by disorderly arranged fibers and a massive inflammatory cell infiltrated in the model group. MF after myocardial infarction was significantly reduced in model + Egb761 group compared with model group.
Our study suggested that EGb 761 could improve HA content and MF after myocardial infarction.