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Rhizoma Polygoni Cuspidati, a Chinese herbal medicine, is recorded first in the book named 'Miscellaneous Records of Famous Physicians' (Ming Yi Bie Lu). As one of its main ingredient, Polydatin has multiple biological actions, such as liver protection, anti-inflammation, antitumor, and are applied to prevent and treat cardiovascular diseases.
60 eight-week-old ApoE-/- mice, fed a high fat diet for 13 weeks. All the ApoE-/- mice were randomized into three groups (n=20): model group (ApoE-/- gourp), Polydatin group (ApoE-/-+ Polydatin group) and Simvastatin group (ApoE-/-+Simvastatin group), fed a high-fat diet. 20 eight-week-old C57BL/6 were treated as the control group, fed a basic diet. After treatment for 13 weeks, we sacrificed all the mice for various measurements. The protein and mRNA level of GRP78 and GRP94, the expression of inflammatory factor, lipid metabolism and the morphology changes of plaque were detected.
The results showed that treatment with Polydatin significantly reduced blood lipid. Polydatin has the anti-atherosclerotic effect. It could reduce the level of NF-κB and TNF-α in plasma. And it could reduce protein and mRNA expression of GRP78, GRP94 and CHOP in aorta. There is no significant difference between the effects of Polydatin and Simvastatin group.
Polydatin has the effect of anti-atherosclerosis and anti-inflammation in ApoE-/- mice. The mechanism of anti-atherosclerosis with Polydatin might be related to the regulation of Endoplasmic Reticulum Stress pathway.