Author + information
- Zhang Bo and
- Lan Huang
The aim of the present study was to investigate the role of genetic polymorphisms of ApoE in carotid artery atherosclerosis and the instability of the plaque.
238 subjects were divided into 3 groups: the instable plaque group, stable plaque group and control group according to the result of carotid ultrasound examination. The genetype of ApoE and serum ApoE concentration was measured. The relationship between the genetic polymorphism of ApoE and the instability of carotid plaque was studied with linear and logistic regression analysis.
①The frequency of ε4 allele in the CAS subjects was higher than the health people. It was higher in instable plaque group than the stable plaque, and this was statistically significant. ②The average of IMT of the subjects with ε4 allele was 1.22mm, which was significant thicker than the subjects without ε4 allele.。③The ApoE ε4 allele is an independent relative factor of the instable plaque when age, sex and blood fat were adiusted in logistic regression analysis. ④The level of Hs-CRP and MCP-1 in serum of the subjects with allele ε4 were higher than the subjects without it, which indicated that the inflammatory activity in subjects with ε4 allele was stronger than the subjects without ε4 allele.
ApoE polymorphism was associated with carotid atherosclerosis and the instability of plaques. Patients with the ApoE4 isoform had a more severe CAS than the subjects without the ApoE e4 allele. Thegenetic polymorphism of ApoE has influenced the arteriosclerosis through adjusting the blood-fat or the chronic inflammation status.