Author + information
- Yongtao Wang,
- Fen Liu,
- Yining Yang,
- Bangdang Chen,
- Xiaomei Li and
- Yitong Ma
The aim of the present study was to assess the association between brashial-ankle pulse wave velocity (baPWV) and ankle-arm index (ABI) and the risk of aortic valve calcification (AVC).
133 cases diagnosed with AVC in the First Affiliated Hospital of Xinjiang Medical University from October 2009 to October 2014 were enrolled as case group, at the same time, 152 case without AVC were enrolled as control group. Demographic characteristics, lifestyle, personal history, family history, laboratory tests and other information of all subjects were collected. The adds ratios (OR) and 95% confidence intervals (CI) of total and type-specific stroke were estimated using logistic regression models.
baPWV was significantly higher in subjects with AVC than that in those without AVC (t = 3.254, P = 0.001), there exists no significant difference of ABI between the two groups (t = 0.144, P = 0.888). Compared to controls in the lowest quartile, after adjustment for age and gender, the cases in the highest quartile of baPWV were also associated with the increased risk of AVC [ OR = 1.297, 95% CI (1.020～1.651), P = 0.034], After further adjustment for influencing factors such as hypertension, diabetes, smoking, triglycerides, uric acid and creatinine, cases in the highest quartile of baPWV had 1.469 times the risk of AVC as did those controls in the lowest quartile [OR = 1.469, 95% CI (1.127～1.915), P = 0.004]. There exist no statistically significance when analysising the relationship between ABI and AVC using Logistic regression models.
The rising baPWV is an important risk factor for AVC, it has a certain value in the prediction and diagnostic assessment of AVC.