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To investigate the anti- fibrotic effects of matrine and related molecular mechanism in experimental diabetic cardiomyopathy.
intraperitoneal streptozotocin injection was used to induce diabetic cardiomyopathy. Animals received intragastric administration of matrine. Cardiac function was assessed by hemodynamic and echocardiographic examinations. Immunofluorescent staining was used to detect type I collagen to evaluate cardiac fibrosis. Western blotting was used to expression levels of TGFβ1 and phosphorylation level of Smad2/3.
The impaired cardiac function was improved by matrine administration which significantly inhibited TGFβ1/Smad signaling pathway which was activated in cardiac tissue. As a result, the expression of type I collagen was found significantly decreased.
Matrine improves cardiac function by attenuating cardiac fibrosis by inhibiting TGFβ1/smad signaling pathway in diabetic cardiomyopathy.