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There were several effects of statin in acute coronary syndrome (ACS) that could extend the clinical benefit beyond the lipid profile modification itself, but the mechanism is not fully clarified. Here we aimed to investigate the role of statin in unstable angina (UA) patients by regulating bood-borne microRNAs (miRNAs) network.
MiRNAs array was performed to detect differentially expressed miRNAs in statin-treated patients with UA. TargetScan and miRanda programs were used to predict miRNAs targets. The PANTHER database via DAVID platform was used to perform signaling pathway analysis. miRNAs targets in vascular endothelial cells, monocytes and platelet were clustered based on CGAP SAGE library or UP tissue-specific library.
There were 21 differentially expressed miRNAs in non-statin patients compaired to healthy controls, and 33 miRNAs in statin-treated patients compaired to non-statin patients. Statin-induced miRNAs function were enriched in angiogenesis, integrin and PDGF signaling pathway. In endothelial cells and platelet, statin-induced miRNAs mainly targeted integrin signaling pathway, and in monocytes mainly targeted cytoskeletal regulation by Rho GTPase pathway.
Statin may play systematic protective roles in UA patients by influencing circulating miRNAs regulatory network.