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Prior studies have found that the increase in IL-17A levels is related to the atrial fibrillation. Whether IL-17A promotes ventricular arrhythmias (VAs) is unknown. This study aimed to investigate the effect of IL-17A on left stellate ganglia (LSG) and ischemia induced VAs.
Sixteen dogs were anesthetized and randomly divided into two groups. 0.1ml IL-17A (25ug/ml)(Group 1, n=8) or saline (Group 2, n=8) was microinjected into LSG. Ventricular effective refractory period (ERP), LSG function measured by blood pressure increases in response to LSG stimulation and LSG neural activity were measured at baseline and 30 minutes after IL-17A or saline microinjection. Acute myocardial infarction (AMI) was induced by left anterior descending coronary artery ligation, and then LSG neural activity and VAs were recorded.
Compared to baseline, microinjection of IL-17A significantly shortened ventricular ERP, enhanced the blood pressure raising response induced by LSG stimulation and increased the frequency and amplitude of the neural activity recorded from LSG in Group 1, whereas no significant change was shown in the Group 2. AMI resulted in a significant increase in LSG neural activity in the Group 2, which were intensified in the Group 1. The incidence of VAs was significantly higher in the Group 1 than that in the Group 2.
Microinjection of IL-17A into LSG may promote ischemia induced VAs by enhancing the neural activity of LSG.