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Despite growing evidence that arterial stiffness has important predictive value on cardiovascular diseases (CVD) for patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mild impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on CVD in this specific population.
We analyzed the measurement of arterial stiffness (carotid-femoral pulse wave velocity [cf-PWV]) and the incidence of major adverse cardiovascular events (MACEs) in 1499 subjects from a 4.8-year longitudinal study.
A multivariate Cox proportional hazards regression analysis showed that in individuals with normal renal function (eGFR≥90 ml/min/1.73 m2), the baseline cf-PWV was not associated with the occurrence of MACEs [HR, 1.398 (95% CI, 0.748-2.613), P=0.293]. In individuals with mild impaired renal function (eGFR<90 ml/min/1.73 m2), a higher baseline cf-PWV level was associated with a higher risk of MACEs [HR, 2.334 (95% CI, 1.082-5.036), P=0.031].
Arterial stiffness is a strong and independent predictive factor for MACEs in individuals with mild impaired renal function (eGFR<90 ml/min/1.73 m2).