Author + information
- Zhou Bingyang and
- Li Jianjun
Big endothelin-1 (ET-1) has been proposed as a novel prognostic indicator of acute coronary syndrome, while its predicting role of cardiovascular outcomes in patients with stable coronary artery disease (CAD) is unclear.
A total of 3154 consecutive patients with stable CAD were enrolled and were followed up for 24 months. The outcomes included all-cause death, non-fatal myocardial infarction, stroke and unplanned revascularization (percutaneous coronary intervention and coronary artery bypass grafting). Baseline big endothlin-1 was measured usingsandwich enzyme immunoassay method. Cox proportional hazard regression analysis and Kaplan-Meier analysis were used to evaluate the prognostic value of big ET-1 on cardiovascular outcomes.
189 (5.99%) events occurred during follow-up. Patients were divided into two groups: events group (n=189) and non-events group (n=2965). The events group had higher levels of big ET-1 compared to non-events group. Multivariable Cox proportional hazard regression analysis showed that big ET-1 was positively and statistically correlated with clinical outcomes (Hazard Ratio: 1.757, 95% confidence interval: 1.198-2.578, p=0.004). The area under the receiver operating characteristic (ROC) curve of big ET-1 in predicting outcomes was 0.563 (p=0.004). Additionally, the Kaplan-Meier analysis revealed that higher big ET-1 presented lower event-free survival (p=0.016).
The present study firstly suggests that big ET-1 is an independent risk marker of cardiovascular outcomes in patients with stable CAD.