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percutaneous coronary intervention (PCI) is one of the dominant methods for revascularization in patient with coronary artery disease (CAD), which accompanied with high incidence of periprocedural myocardial injury (PMI). However, the relationship of lipid profiles with PMI in patients after PCI was controversial.
We extensively searched in the MEDLINE to identify all the studies that reported to evaluate the relationship of lipid profiles with PMI undergoing PCI. Searches combined free-text and MeSH terms relating to “myocardial infarction” or “myocardial injury” and “peri-procedural” or “periprocedural”. Reference lists from the identified articles were manually examined for relevant new articles. The final literature search was finished on March 06th, 2015 considered studies in English. Finally, 8 relevant studies were included in our review.
We found that PCI related PMI might be correlated positively to those lipid profiles such as total cholesterol, triglyceride, Low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol, the ratios of LDL-C to high-density lipoprotein cholesterol (HDL-C), the ratios of HDL-C to apolipoprotein A-I, the ratio of eicosapentaenoic acid to arachidonic acid, Lectin-like oxidized low-density lipoprotein receptor-1. Besides, there were controversial associations between PMI and high-density lipoprotein cholesterol (HDL-C).
Most of lipid profiles were correlated positively to PMI in patients undergoing PCI, except HDL-C. Unfortunately, almost all studies failed to provide definite mechanism of its findings. Thus, in our opinion, further reaches about mechanisms are needed.