Author + information
- Wang Yina,
- Qiongli Yin,
- Shangyan Liang,
- Benrong Zheng,
- Qingling Li,
- Mei Li and
- Xiaoming Ye
To investigate the relationship between serum lipoprotein-associated phospholipase (Lp-PLA2) level and carotid artery arteriosclerosis in patients with impaired glucose tolerance (IGT).
Blood lipid and hs-CRP of 168 IGT patients (male: 86, female: 82) were detected. The Lp-PLA2 concentration of limosis blood serum was determined by ELISA method. High frequency ultrasound was used to detect IMT and plaques. According to the results of High frequency ultrasound, the 168 cases were divided to three groups: 52 cases with normal carotid arteries; 55 cases with intima-media incrassation of carotidarteries; and 61 cases with plaque. The correlation between the level of Lp-PLA2 and carotid artery disease was analyzed．
The concentration of LDL, hs-CRP and Lp-PLA2 were higher in the groups with plaque than in the group with normal carotidarteries and intima-media incrassation of carotidarteries, and the differences were significant (P<0.05). Nosignificant difference was found in TG and LDL among the three groups(P>0.05). The concentration of Lp-PLA2 are positively correlated with TC, LDL and hs-CRP (r=0.323, 0.226, 0.215, P<0.01, 0.05, 0.05). Nosignificant diference was found between Lp-PLA2 and TG(r=0.136, P=0.5).
The Lp-PLA2 was associated with carotid artery arteriosclerosis in patients with IGT. It may play as a factor of accelerating atherosclerosis, especially in the condition of exisitence of plaque. The mechanism maybe related to lipids and inflammation.