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To explore the relationship between (FGF23) gene polymorphism and Coronary heart disease (CHD) in Chinese Han population.
A total of 431 subjects including 231 CHD patients and 200 non-CHD subjects were selected in the Department of Cardiology, Daping Hospital, Third Military Medical University between May 2014 and March 2015. All the subjects were unrelated Chinese Han population and had been examined by coronary angiography. The Sequenom Massarray system was used for the genotyping of three FGF23 gene Tag single-nucleotide polymorphisms, namely rs7955866, rs13312756, and rs3812822. The frequencies of the alleles, genotypes, and haplotypes of these TagSNPs were compared between the CHD and control groups.
The frequencies of rs7955866 A and rs3812822 C alleles in CHD group were significantly higher than in control group (P<0.001), and the distribution of the loci genotypes was also significantly different between the two groups (P<0.01). Univariate Logistic regression analysis showed that the risk of developing CHD in the subjects carrying rs7955866 GA genotype was 2.146-fold of the ones carrying GG genotype (P=0.01, OR=2.146, 95%CI: 1.393-3.306), and rs3812822 CT genotype carriers also had a higher risk compared with the ones with TT genotype (P= 0.01, OR=2.010, 95%CI: 1.327 -3.046). Adjusting for the confounding factors just like gender, age, BMI, smoking history, drinking history, history of hypertension and hypercholesterolemia. the results showed that the SNPs at rs7955866 (P<0.001, OR=2.478, 95%CI: 1.613-3.806) and rs3812822 (P<0.001, OR=2.123, 95%CI: 1.439-3.132) were independently associated with the development of CHD. The ACC Haplotype consisted by rs7955866-rs13312756-rs3812822 was also shown to have an effect on increasing CHD risk (P<0.001; OR=2.074, 95%CI: 1.391-3.091).
FGF23 gene polymorphisms were related to the risk of CHD in Chinese Han population.