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To evaluate the safety and efficacy of percutaneous ventricular partitioning (PVP) using the Parachute system in ischemic heart failure patients with apical aneurysm.
Safety defined as the successful delivery and deployment of the ventricular partitioning device (PVD) implant, as well as every 3-month functional, clinical, and hemodynamic effectiveness were followed-up.
Nineteen patients (aging 68.1±8.2 years) suffered from left ventricular aneurysm and heart failure patients caused by anterior myocardial infarction were enrolled. Ventricular partitioning device implantation was successful in 18/19 (83%) patients. In one patient, the VPD wasn't implanted for the unsatisfactory landing. By 252±170 days follow-up, there was no cardiac deaths or HF hospitalization. New York Heart Association symptom class (2.72±0.6 vs 1.78±0.38, P<0.01) and 6 min walk test (462±96 vs 484±87m, P<0.01) were improved 3 months after PVP. Left ventricle end-diastolic volume index and end-systolic volume index were reduced from 137.4±19.1 and 89.7±22.3 mL/m2 preimplant to 125.6±18.5 and 78.8±20.7 mL/m2 (end-diastolic volume index, P=0.0056; end-systolic volume index, P=0.0019) with improved left ventricle ejection fraction (34.8 ±8.13 vs 41.3±6.2%, P=0.031).
Our preliminary experience on PVP using Parachute system demonstrates its feasibility and safety, and that VPD implantation improves LV haemodynamics and functional capacity in short term following the procedure.