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To explore the value of Tei index and brain natriuretic peptide (BNP) on predicting major adverse cardiovascular events (MACE) in ischemic cardiomyopathy patients with two years long-term follow up.
The study enrolled 238 patients with ischemic cardiomyopathy. The patients were further divided into four groups according to the median of Tei index and BNP. G1 group (Tei≤0.66, BNP≤532.6 ng/ml, n=70), G2 group (Tei≤0.66, BNP > 532.6 ng/ml, n=51), G3 group (Tei > 0.66, BNP≤532.6 ng/ml, n=50), G4 group (Tei > 0.66, BNP > 532.6 ng/ml, n=67). Incidence of MACE was observed during (20.02±0.43) month follow up. All statistic work was carried out with software of SPSS 13.0.
There was a significant positive correlation between Tei index and BNP (r=0.582, P=0.000). Tei and LVEF (β=0.658, -0.465, P < 0.05) were significant independent predictors for BNP. Kaplan-Meier survival analysis showed that the incidence of without MACE at 24 months was significant difference in four groups (Log-Rank test, χ2=9.975, P=0.019). Cox multivariate analysis revealed that Tei (OR=4.581, 95% CI: 1.683-12.473, P=0.003) and BNP (OR=3.022, 95% CI: 1.385-6.593, P=0.005) were independent prognostic risk factors of MACE. The cutoff value of Tei to predict MACE was 0.81 (AUC=0.739, 95% CI: 0.673-0.804, P=0.000), and the cutoff value of BNP was 848.5 ng/L (AUC=0.717, 95% CI: 0.649-0.785, P=0.000). AUC of Tei and BNP for predicting MACE was 0.781 (95% CI: 0.721-0.841, P=0.000), the sensitivity and specificity were 72.5%, 76.9% respectively.
Tei index and BNP are associated with MACE in two years follow up. These two parameters could be used to predict long-term MACE in ischemic cardiomyopathy patients.