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The retrospective study was designed to analyze the dynamic relation between the metabolic syndrome (MS) and the coronary artery disease, to analyze the impacts of the MS components for the progression of the coronary artery lesion.
245 patients who underwent a second coronary angiography or coronary 320-slice CTA at a minimum interval of 6 months after their first examination in the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2015, were divided into non-MS group and MS group. All the clinical data were collected and coronary progression was defined as the difference of Gensini Score >0 point per year, notable coronary progression was defined as the difference of Gensini Score ≥1 point per year. All statistics tests were operated with program SPSS 16.0 and P<0.05 was considered statistically significant.
245 patients were enrolled, of whom 136 (55.5%) patients were male, with an average age of 66.02±10.76 years, 88 (36%) patients were diagnosed with MS. The incidences of CAD (71.3% VS 79.5%, P=0.158), multiple coronary artery lesions in CAD patients (51.8% VS 61.4%, P=0.203) and stent implanting (73.2% VS 77.1%, P=0.553) were similar in both groups. But the first Gensini score [19.0 (6.0,46.0) VS 11.0 (2.0,41.0), P=0.042], the rate of Gensini score progression [2.84 (0,11.91) VS 0.0 (0,4.38), P=0.007] and the incidence of notable progression (61.4% VS 45.2%, P=0.015) of group MS were significantly higher than the other group's. Though the correlation analysis, the incidence of hypertension were correlated with the coronary progression (r=0.219, P<0.001) and the notable coronary progression (r=0.270, P<0.001) positively. The duration of hypertension was correlated with the rate of Gensini score progression positively (r=0.234, P<0.001). Though the regression analysis, for the coronary artery, the hypertension was the risk factor (OR 3.011, P=0.001).
The severity of coronary artery lesion was more serious and the progression of CAD was faster in patients with metabolic syndrome. As the major risk factor in our study, hypertension would promote the progression of CAD.