Author + information
- Zixiang Yu1,
- Nuremanguli Abudukeremu1,
- Siew-Pang Chan2,
- Yi-Ning Yang1,
- Xiao-Mei Li1,
- Fen Liu1 and
- Yitong Ma1
To ascertain the in-hospital and long-term (≥1 year) outcomes of CAD patients with LV systolic dysfunction (ejection fraction ≤40%) after PCI according to a meta-analysis.
A systematic literature search and a series of random-effect meta-analyses were conducted to evaluate the short- and long-term outcomes of PCI of the selected studies. Single-center studies and those that did not report evidence on long-term mortality were excluded in the analysis. All statistical tests were performed with 95% confidence intervals. A p-value of less than 0.05 was considered statistically significant.
A total of 25 studies involving 5,471 patients (78% males, average age 65.1 years) were identified. The average follow-up duration was approximately 27 months. The majority of patients had multi-vessel disease (68%), hypertension (66%), hypercholesterolemia (59%), and prior myocardial infarction (MI) (58%). The meta-analysis showed that the in-hospital occurrence of major adverse cardiac events (MACE), deaths, MI, and repeat revascularization (RR) after PCI were controlled at 4%, 2%, 2%, and 1%, respectively. The pooled estimates for long-term outcome were 40% MACE, 20% deaths, 4% MI, and 21% RR. There was no significant difference in mortality risk when PCI was compared with CABG (p=0.71).
PCI carries acceptable short- and long-term outcomes for CAD patients with LV systolic dysfunction.