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The promoter -565C/T variant variant and the R219K variant in exon 7 of the ATP binding cassette transporter A1 (ABCA1) were found to be associated with the risk of coronary heart disease (CHD) in western populations. Our study was designed to illustrate the association of these two SNPs with CHD in the Chinese Han people.
A cohort of 519 patients with documented CHD and 541 normal controls were genotyped by the highly sensitive ligase detection reaction.
The frequencies of the TT genotype at the -565C/T locus revealed no difference between CHD patients and controls. In the subgroup analysis, the frequency of the AA genotype of R219K in CHD patients with type 2 diabetes mellitus (DM) was lower than in the controls.
Our results suggested that the AA genotype at the R219K locus protect against CHD in patients with type 2 DM in the Chinese Han population.