Author + information
- Jin Yanyan,
- Zhang Xin-yong,
- Ai Hui,
- Zhu Xiao-lin,
- Wang Jing and
- Gao Hai
Inflammation plays an important role in the pathophysiology of acute ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to investigate the effect of the inflammatory factors in patients with acute myocardial infarction complicated by CS treated by the Shenfu and IABP.
This study enrolled 60 patients with STEMI complicated by CS, and all patients underwent IABP and emergency percutaneous coronary intervention (PCI). All patients were randomly assigned to the treatment of the Shenfu. All patients were divided into 2 groups according to whether or not to give the Shenfu treatment: the IABP group,the IABP +Shenfu group. To compare the two groups in aspects: clinical setting, left ventricular function, biochemical indicator, Inflammatory factors including of C-reactive protein (CRP), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). MACE events were compared between the two groups of patients in-hosipital and follow up.
The two groups were comparable in aspects: age, gender, old myocardial infarction, history of previous revascularization, diabetes mellitus, basic biochemical parameters, etc. The patients in the IABP+ Shenfu group accepted IABP support treatment times were significantly shorter than the patients in the IABP group (52.87±28.84 VS 87.45±87.31 P=0.047). In the patients of the IABP+ Shenfu group,the peak of CRP appeared in 24 hours after PCI operation. The peak of CRP in the patients of the IABP+ Shenfu group was significantly lower than that in the IABP group(31.27 + 3.93 VS 34.62 P=0.001). The increasing range of TNF-α in the patients of the IABP+ Shenfu group was significantly lower than that in the IABP group (182.29 + 22.79 vs 195.54 + 12.02 P = 0.007). The increasing range of IL-1 in the patients of the IABP+ Shenfu group was significantly lower than that in the IABP group(214.98±29.22 VS 228.60±7.03 P=0.019) The logist analysis found that ΔTNF-α is independent risk factors of in-hospital MACCE events (OR 0.973 95%CI 0.890-0.987 P=0.014) in patients with STEMI and CS.
The patients with STEMI complicated by CS were treated by IABP, and at the same time they accepted the treatment of the Shenfu which could reduce the inflammatory reaction of patients, so that they reduced the dependence of CS on IABP and shortened the course of disease in patients with CS.