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This study aims to evaluate whether the plasma level of Hcy is related to the progression of NCCLs after percutaneous coronary stent implantation in elderly patients with acute coronary syndrome (ACS).
A total of 223 elderly patients (≥65 years old) with acute coronary syndrome (ACS) undergoing stent implantation and follow-up coronary angiography were enrolled. Laboratory determination comprised of blood sample evaluation for Hcy was carried out before baseline coronary intervention. The patients were classified into two groups according to the blood Hcy tertiles (≥15 mmol/l or <15 mmol/l). Patients were followed up for 12.2 months. NCCL progression was assessed by three-dimensional quantitative coronary angiography.
A significantly higher ratio of NCCL progression was observed in the group with baseline homocysteine concentrations above 15 mmol/l compared to the group with concentrations below 15 mmol/l (41/127, 32.3% vs. 14/96, 14.6%, P = 0.002). Multivariate Cox regression analysis showed that homocysteine and diabetes mellitus were independent risk factors for NCCL progression. The crude hazard ratio (HR) of NCCL progression for homocysteine level was 1.056 (95% CI 1.01-1.104, P = 0.015). The adjusted HR of NCCL progression for homocysteine level was 1.024 (95% CI 1.007-1.042, P = 0.007). The adjusted HR of NCCL progression for diabetes mellitus was 1.992 (95% CI 1.15-3.44, P = 0.013).
Hcy is an independent risk factor for NCCL progression after 12 months of follow-up in elderly patients with ACS who had undergone percutaneous coronary stenting.