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In order to identify the value of prognosis, we assayed level of serum soluble ST2 (sST2) in AMI patients and analyzed the correlation with NT-proBNP, which can provide a theoretical basis for early intervention of AMI patients.
①A total of 56 AMI patients admitted to Cardiology Department of the First Hospital of Shan Xi Medical University from Nov. 2014 to Mar. 2015, and 20 controls were selected. ②The collection of general information: collect the results of clinical data, laboratory parameters and ultrasonic cardiogram, and record the cardiovascular events of AMI patients during hospitalization, including post-infarction angina, heart failure and death. ③All AMI patients underwent coronary angiography, who met coronary angiography indications. We assessed severity of coronary artery through improved Gensini scoring system and analyzed the relationship between the degree of coronary artery disease and sST2 level. ④Statistical analysis: Using SPSS17.0 statistical software for statistical analysis. P <0.05 was considered significant differences.
①The comparion of baseline sST2 level between AMI group and the control group: serum sST2 baseline level of AMI was 10.30(7.21∼20.14)ng/ml, sST2 level of control group was 8.35(6.02∼9.66)ng/ml, the difference between the two groups was statistically significant (P <0.05). ②The change of sST2 level with AMI: the sST2 level of AMI on the third day after admission was (5.45∼14.72)ng/ml, which was lower than first day 10.30 (7.21∼20.14) ng/ml, the difference was statistically significant (P <0.05). ③The patients was divided into <13 group, 13 to 26 group, 26 to 52 group and >52 group according to Gensini score, the difference of sST2 level among four groups was statistically significant (P <0.05) and the sST2 level of Gensini score >52 group was highest. ④The relationship between sST2 level of AMI patients and heart function: the sST2 levels of killipI-II patients were significantly lower than killip III-IV (P<0.05); the sST2 levels in patients with LVEF<50% were higher than LVEF≥50%(P<0.05). ⑤The short-term prognosis of sST2 in AMI patients: area under ROC curves of sST2 and NT-proBNP were 0.814 and 0.711, the AUC of sST2 was higher than NT-proBNP, the difference was statistically significant (P <0.05); there were differences with different prognosis in AMI (P <0.05), the sST2 level of sudden cardiac death patients was higher than other groups.
①The level of sST2 were significantly increased at the early time of AMI and trended lower from the first day(average 20.2h after AMI) to the third day(average 68.2h after AMI) after AMI; ②With aggravation of stenosis in coronary artery, the sST2 levels was elevated (except Gensini score <13 group); ③The poorer cardiac function with AMI patients, the higher level of sST2; ④The short-term prognotic value in patients with AMI was higher than NT-proBNP, the short-term prognosis of higher sST2 patients was poorer.