Journal of the American College of Cardiology
Volume 68, Issue 17, October 2016 DOI: 10.1016/j.jacc.2016.07.762
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Original Investigation

Prediction of Poor Outcome After Transcatheter Aortic Valve Replacement

Suzanne V. Arnold, Jonathan Afilalo, John A. Spertus, Yuanyuan Tang, Suzanne J. Baron, Philip G. Jones, Michael J. Reardon, Steven J. Yakubov, David H. Adams, David J. Cohen and U.S. CoreValve Investigators

Table 3

Table 3

Clinical Models: Association of Frailty and Geriatric Domains With Poor Outcomes

6-Month Clinical Model1-Year Clinical Model
OR (95% CI)p ValueOR (95% CI)p Value
Base model∗
 KCCQ-12-os0.92 (0.87–0.96)0.81 (0.78–0.85)
 Mean aortic valve gradient, per 10 mm Hg0.81 (0.76–0.87)0.86 (0.80–0.92)
 Home oxygen1.62 (1.22–2.17)1.54 (1.13–2.10)
 Serum creatinine, per 1 mg/dl1.24 (1.02–1.51)1.37 (1.12–1.68)
 Mild dementia/mild cognitive impairment†1.31 (1.08–1.59)1.30 (1.07–1.59)
 Moderate/severe dementia†1.72 (0.82–3.62)1.75 (0.78–3.97)
 Atrial fibrillation/flutter1.40 (1.16–1.70)1.28 (1.05–1.55)
 Diabetes mellitus0.77 (0.63–0.94)0.93 (0.76–1.14)
c-index = 0.637‡c-index = 0.665‡
Frailty syndrome1.29 (1.08–1.55)0.0041.13 (0.93–1.36)0.209
c-index = 0.641IDI p = 0.005c-index = 0.665IDI p = 0.218
Geriatric components
 Disabilities, per 1 ADL1.29 (1.19–1.39)<0.0011.22 (1.12–1.33)<0.001
 Unintentional weight loss1.51 (1.17–1.95)0.0011.53 (1.15–2.04)0.003
c-index = 0.656IDI p = 0.007c-index = 0.676IDI p = 0.008

Abbreviations as in Tables 1 and 2.

  • ↵∗ Odds ratios and confidence intervals for the base model are based on the original model derivations in PARTNER (Placement of Aortic Transcatheter Valve) (7).

  • ↵† Mini-Mental State Examination score: 0 to 18 for moderate/severe dementia, 19 to 27 for mild dementia/mild cognitive impairment (25).

  • ↵‡ Represents the discrimination of the existing base models in the CoreValve dataset.

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