Author + information
- da hyon lee1,
- Jeong Hoon Yang2,
- Joo Yong Hahn3,
- Cláudia Jorge4,
- sang hoon lee5,
- Fausto J. Pinto6 and
- Seung-Hyuk Choi7
- 1Columbia University Medical Center, seoul, Korea, Republic of
- 2Samsung Medical Center, Seoul, Korea, Republic of
- 3Interventional Cardiologist, Seoul, Korea, Republic of
- 4Cardiology Department, Santa Maria University Hospital, CHLN, CAML, CCUL, Faculty of Medicine, University of Lisbon
- 5Samsung Medical Center, Seoul, Korea, Republic of
- 6Cardiology Department, Santa Maria University Hospital, CHLN, CAML, CCUL, Faculty of Medicine, University of Lisbon
- 7Samsung Medical Center, Seoul, Korea, Republic of
Men were more likely to suffer vasospastic angina (VSA) than women, but the gender difference in clinical characteristics and prognosis of VSA patients was not fully elucidated. We sought to investigate clinical characteristics and prognostic predictors in both genders of VSA patients.
We included patients with positive result on intracoronary ergonovine provocation test between January 2003 and December 2014. A total of 986 patients were analyzed according to gender (male [n=838] versus female [n=148]) for clinical characteristics and major adverse cardiac event (MACE). MACE was defined as a composite outcome of cardiac death, acute myocardial infarction, revascularization, or re-hospitalization due to recurrent angina.
Female patients were younger and were associated with a lower prevalence of smoking and coronary stenosis, compared with male patients. The risk for MACE was similar between male and female genders (hazard ratio [HR], 0.95; 95% confidence interval [CI], 0.65 to 1.39; p = 0.79). In multivariable prediction models for MACE, high-sensitivity CRP (hs-CRP) level was a significant predictor of MACE in male patients (HR, 1.95; 95% CI, 1.25 to 3.06, p = 0.003), while there was no significant predictor of MACE in female patients. There was a significant interaction between hs-CRP level and MACE rate across the gender (interaction p = 0.02).
Gender related differences in several clinical characteristics were noted in VSA patients. Long-term clinical outcome was not different between both genders, but prognostic predictor differs according to gender.
OTHER: Womens Health Issues