Author + information
- Valeria Paradies1,
- George Vlachojannis2,
- Kees-Jan Royaards3,
- Floris Kauer4,
- Jochem Wassing5,
- Martin van der Ent6 and
- Pieter Smits7
- 1Maastad Ziekenhuis, Rotterdam, Netherlands
- 2Factoid Team/CRF, New York, New York, United States
- 3Unknown, Rotterdam, Netherlands
- 4Department of Cardiovascular Surgery, University of Tübingen, Germany, Rotterdam, Netherlands
- 5Maasstad Hospital, Capelle a/d IJssel, Netherlands
- 6Unknown, Alphen aan den Rijn, Netherlands
- 7Maasstad Ziekenhuis, Rotterdam, Netherlands
The resorption process of Absorb bioresorbable scaffold (BRS) struts covering jailed side branch (SB) ostia has not yet been fully investigated.
We performed both 2D and 3D OCT analysis of patients treated within the ABSORB Cohort B at our center. According to the protocol the patients underwent serial angiography and intravascular imaging evaluation at 1,3 and 5 years post implantation (OCT at 3 and 5 years follow-up). Orifice SB area and mean thickness of tissue bridge covering SB were calculated from 2D assessment. The number of SB orifice compartments separated by BRS struts was analyzed by using 3D OCT reconstruction.
We identified a total of 3 SBs ostia in the segments treated with BRS. Between 3 and 5 years follow-up a significant decrease of mean tissue bridge thickness covering SBs ostia was observed (423±75 μm at 3 years vs. 270±87 μm at 5 years; p=0.03; Fig). Moreover, there was a trend towards an increase of calculated SBs area (3.36±2.51mm2 at 3 years vs. 3.76±2.88mm2 at 5 years; p=0.06). Using 3D reconstruction, visual assessment showed a decrease in number of compartments in two out of three SBs ostia.
In our serial OCT series of BRS struts covering SBs ostia, we observed a consistent disappearance of the Absorb scaffold struts at the jailed SB together with SB orifice area enlargement as well as significant decrease of tissue bridge formation from 3 to 5 years follow-up. These findings show a dynamic and beneficial effect in time on jailed SB with BRS.