Author + information
- Cristiano G. Bezerra1,
- Gonzalo Maso Talou2,
- Carlos A. Bulant2,
- José Mariani Jr.1,
- Fábio A. Pinton3,
- Breno A.A. Falcão1,
- Antonio E. Filho1,
- Raul A. Feijóo2,
- Pedro A. Lemos1 and
- Pablo J. Blanco2
Tridimensional reconstruction of the coronary arteries have played a major role in the understanding of the onset and progression of atherosclerotic plaque, plaque rupture and its hemodynamics repercussion. Our aim is to validate an automated algorithm that allows obtaining tridimensional model from integration of IVUS with conventional AX and compare with the gold standard CCTA, in terms of geometric features.
Multicenter study wich enrolled a total of 28 patients (34 arteries) with diagnosed or suspected chronic coronary disease who underwent multimodal evaluation (CCTA, IVUS and AX) by clinical indication. After extracting the centerlines of the vessel lumen in IVUS-AX combination, we compared the models derived from the new algorithm in relation to the geometrical characteristics obtained from CCTA (figure).
There was a good correlation between the models in the following characteristics: bending energy, twisting energy, total curvature, total combined curvature, aspect ratio, total torsion, volume, area and radius (rho> 0.64 and p <0.01). The IVUS-AX model showed greater mean radius (1.4 mm vs. 1.3, p <0.01), greater cross-sectional area (7.5 mm2 vs. 6.6, p = 0.02) and a higher amount of lateral branches (5.4 vs 2.2; p <0.01) compared to CCTA model.
|Total curvature (cm-1)||43.12±18.77||47.83±17.97|
|Total torsion (cm-1)||258.25±111.97||239.95±85.50|
|Number of branch||5.4 ± 2||2.2 ± 1.3|
Mean and standard distribution for each geometric feature computing in the different arterial models.
The new tridimensional model IVUS-AX has a good correlation in terms of geometric features with the CCTA and define more accurately the amount of lumen wich can impact in other indices derived from the model as shear stress or flow simulations.