Author + information
- Rehana de Vries1,
- Masieh Abawi2,
- Pierfrancesco Agostoni3,
- Pieter Doevendans4,
- Pieter Stella4 and
- Marielle Emmelot-Vonk1
Transcatheter aortic valve replacement (TAVR) is frequently associated with new cerebral ischemic lesions detected with diffusion weighted magnetic resonance imaging (DWMRI) which could result in cognitive decline. The aim of this study was to prospectively evaluate the changes of cognitive performance after TAVR.
Eligible patients were prospectively enrolled and periprocedural, clinical and imaging data were collected. Cognitive status was measured before and 3-6 months after the procedure using Mini Mental State Examination (MMSE), quantitative clock-drawing test, Trail Making Test (TMT) and a verbal memory test.
Fifty-five participants (mean age 80±6 years, 47% male) were enrolled from whom 58% (n=32) completed the neuropsychological assessment before and during the follow-up time. Patients who did not complete the follow-up were comparable in age (78±6 years) and level of education. Postoperative, immediate verbal memory significantly improved compared to baseline (29.9±4.1 vs. 28.0±4.7, p=0.02), and a trend toward better delayed verbal memory was seen during the follow-up (4.1±2.2 vs. 4.7±1, p=0.08).
Patients undergoing transcatheter aortic replacement were less likely to develop cognitive decline at short-term follow-up. However, there was significantly improvement in immediate verbal memory suggesting better cerebral perfusion after the procedure.
STRUCTURAL: Valvular Disease: Aortic