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Obesity is associated with many cardiovascular risk factors. The goal of this study was to evaluate any association between obesity and ST elevation myocardial infarction (STEMI) after multivariate adjustment.
We used ICD-9 Codes for obesity and ST elevation myocardial infarction from the Nationwide Inpatient Sample (NIS) database. We used available date from the year of 2003 to 2011. We used uni- and multivariate analysis to evaluate any association between obesity and the occurrence of STEMI.
2003 database contained a total of 7,977,728 patients. Obesity was present in 335,772 patients. STEMI occurred in 1.3% of obese vs. 0.8 % of non-obese control (OR: 1.57, CI 1.52-1.62, p<0.0001). Obesity remained associated with STEMI over the years studied but this association showed gradual decline to the lowest level in 2011 reaching similar rate to non-obese patients (in 2011 data base STEMI occurred in 0.6% of obese patients vs 0.5% of non-obese (OR: 1.34, CI 1.30-1.39, p< 0.001). Using multivariate analysis adjusting for age, hypertension, hyperlipidemia, diabetes and smoking, obesity remained independently associated with the occurrence of STEMI.
Obesity has been consistently associated with the occurrence of STEMI. However, its association has steadily declined reaching almost the level of non-obese population in 2011. This suggest, that aggressive risk factor treatment in recent years had greater benefit in high risk obese patients in the prevention of myocardial infarction.
CORONARY: Acute Myocardial Infarction