|Efforts to improve the evidence base of medicine have a long history over several centuries.|
|The EBM Movement: a group of epidemiologists from McMaster University launched EBM in the early 1990s.|
|The Cochrane Collaboration: founded in the United Kingdom with DH sponsorship by members of the EBM movement.|
|Limitations of EBM: Relegation of clinical judgment and mechanistic reasoning, and over-reliance on the reliability of clinical trials and systematic reviews.|
|Adverse effects on clinical practice: bias of the “easily measurable” risks relegating less tangible values, such as patient experience and dignity, and knowledge creation|
|Conflation of comparative research and original science: comparative research evaluates what is known; original science seeks to explore what is unknown|
|The Future of EBM: relocated within the wider context of medicine and medical science|
DH = Department of Health; EBM = evidence-based medicine (as it was launched in the 1990s).